Methodology and Evaluation (original papers)

Nilsson GE, Zhai H, Chan HP, Farahmand S, Maibach HI.

Skin Res Technol. 2009 Feb;15(1):6-13.


Comparison of instruments for investigation of microcirculatory blood flow and red blood cell concentration.

O’Doherty J, McNamara P, Clancy NT, Enfield JG, Leahy MJ.

J Biomed Opt. 2009 May-Jun;14(3).

“Go with the flow” a review of methods and advancements in blood flow imaging.

Daly SM and Leahy MJ

Journal of biophotonics, 2013

Applications (original papers)

Comparison of tissue viability imaging and colorimetry: skin blanching.

Zhai H, Chan HP, Farahmand S, Nilsson GE and Maibach, HI.

Skin Research and Technology, 15, 20-23, 2009.

Tissue viability imaging: mapping skin erythema.

Zhai H, Chan HP, Farahmand S, Nilsson GE and Maibach, HI.

Skin Research and Technology, 15, 14-19, 2009.

Enhancement of bioavailability by lowering of fat content in topical formulations

Wirén K, Frithiof H, Sjöquist H and Lodén M.

Brit J Derm, 2009 Mar, 160(3):552-6.

Tissue viability imaging: Microvascular response to vasoactive drugs induced by iontophoresis

Henricson J, Nilsson A, Tesselaar E, NIlsson G and Sjoberg F.

MIcrovascular Research, Vol 78, Issue 2, September 2009, pp 199-205.

Tissue Viability (TiVi) imaging:temporal effects of local occlusion studies in the volar forearm

MacNamara PM, O´Doherty J, O´Connell M-L, Fitzgerald BW, Anderson C, Nilsson GE, Toll R and Leahy, ML.

J Biophotonics, 3, No. 1-2, 66-74, 2010

Tissue viability imaging for assessment of pharmacologically induced vasodilatation and vasoconstriction in human skin.

Petersen LJ, Zacho HD, Lyngholm AM and Arendt-Nielsen L.

Microvascular Reserach, Vol 80, Issue 3, December, 499-504, 2010.

Hyperaemic changes in forearm skin perfusion and RBC concentration after increasing occlusion times

Farnebo S, Thorfinn J, Henricson, J and Tesselaar E.

Microvascular Reserach, Vol 80, Issue 3, December, 412-416, 2010.

Capsaicin-induced neurogenic inflammation in the skin in patients with symptoms induced by odorous chemicals

Holst H, Arendt-Nielsen L, Mosbech H, Serup J and Elberling J.

Skin Reserach and Technology, Vol 17, No 1, pp 82-90, 2011.

Tissue Viability Imaging (TiVi) in assessment of divergent beam UV-B provocation

O´Doherty J, Henricson J, Enfield D, Nilsson GE, Leahy MJ and Anderson CD.

Arch Dermato Res, Mar, 303(2), 79-87, 2011

No skin reactions to mineral powders in nickel-sensitive subjects.

Lodén M, Nilsson G, Parvardeh M, Neimert Carne K and Berg M.

Contact Dermatitis, 66, 210-214, 2012

Dynamic Microvascular responses with a high speed in TiVi imaging systems

O´Doherty J, MacNamara PM, Fitzgerald BW and Leahy, M.

J Biophotonics, 4, No. 7-8, Aug, 509-513, 2011.

Polarized light spectroscopy for measurement of the microvascular response to local heating at multiple skin sites

Tesselaar E, Bergkvist M, Sjöberg F and Farnebo S

Microcirculation, Vol 19, Issue 8, pages 705-713, November 2012.

Physiological influence of basic petubations assessed by non-invasive optical techniques in humans

Svanberg K, Wollmer P, Anderssom-Engels S and Åkeson J.

Applied Physiology, Nutrition and Metabolism. Vol 36, No 6, Dec, 946-957, 2011.

Assessment of Blood Flow Changes in Human Skin by Microdialysis Urea Clearance

Farnebo S, Zettersten E, Samuelsson A, Tesselaar E.

Microcirculation, 18:Issue 3,198-204, april 2011.

Development of cumulative irritation model for incontinence-associated dermatitis

Larner J, Matar K, Goldman VS and Chilcott RP.

Arch Dermatol Res, 307:39-48, 2015

Tissue Viability Imaging for quantitative user-independent assessment of erythema, blanching and other skin parameters

Nilsson GE.

SPC (Soap, Perfumery & Cosmetics) Regulatory & Testing,(Supplement), p50-53, 2014.

Validation of phototesting for estimation of individual skin ultraviolet sensitivity based on a lengthwise attenuation ultraviolet B field

Pettersson E, Anderson CD, Henricsson J and Falk M.

Journal of Medical Engineering & Technology, p 1-8, 2014.

Correcting for possible tissue distortion between provocation and assessment in skin testing: the divergent beam UVB photo-test

O’Doherty J, Henricson J, Falk M and Andersson CD.

Skin Res Technol. 2013 Nov;19(4):368-74.

Tissue viability imaging of skin microcirculation following exposure to whole body cryotherapy (-110C) and cold water immersion (8C)

Costello JT, McNamara PM, O´Connell ML, Algar LA, Leahy MJ and Donnelly A.

Archives of Exercise in Health and Disease, 4(1), 243:250, 2014.

Microvascular Imaging: technoiques and opportunities for clinical physiological measurements

Allen J, Howell K,

Physiological Measurements 35(2014) R 191-R14.

Real Time diffuse reflectance polarisation spectroscopy imaging to evaluate skin microcirculation

O’Doherty J, Henricson J, Nilsson GE, Anderson C and Leahy M.

Proc SPIE 6631, Novel Optical Instrumentation for Biomedical Applications III, Munic, Germany 2007.

Short-term sensory and cutaneous vascular responses to therapeutic ultrasound in the forearms of healthy volunteers

Shaik S, MacDermid JC, Birmingham T, Grewal R and Farooq B,

J Therapeutic ULtrasound, 2014, 2:10

Short Term sensory and cutaneous vascular responses to cold water immersion in patients with distal radius fracture (DRF)

Shaik SS, Macdermid JC, Birmingham T and Grewal R,

SM J Orthop. 2015; 1(1):1003.

Inhibitory activity of Sargassum hemiphyllum sulfated polysaccharide in arachidonic acid-induced animal models of inflammation

Hwang PA, Hung YL and Chien SY,

J of Food and Drug Analysis 23 (2015), 49-56.

Analysis of Red Blood Cell Concentration in the Digits of the Hand of Controls and Participants with Carpal Tunnel Syndrome: A Response to Temperature

Constand MK and MacDermid JC

Critical Reviews in Physical and Rehabilitation Medicine.

Persistant PORT-a-CATH A-related fistula and fibrosis in a breast cancer patient successfully treated with local ozone application

Clavo B, Lopez SM and Robaina F.

Journal of Pain and Symptom Management 43:e3-e6, 2012.

Non-Invasive Measurement of Skin Microvascular Response during Pharmacological and Physiological Provocations

Iredahl, F, Löfberg, A, Sjöberg, F, Farnebo, S and Tesselar, E.

Plos ONE | DOI:10.1371/journal.pone.0133760, August 13, 2015

Assessment of microcirculation of the skin using Tissue Viability Imaging: A promising technique for detecting venous stasis in the skin

Bergqvist M, Henricson J, Iredahl F, Tesselaar, E, Sjöberg F and Farnebo S.

Microvascular Research, Vol 101, September 215, p 20-25.

Reflectance spectroscopy: to shed new light on the capillary refill test

John RT, Henricson, J, Nilsson, GE, Wilhelms D and Anderson CD.

J of Biophotonics, Vol 11, Issue 1, Jan 2018.

Towards a broader use of phototesting: in Research, clinical practice and skin cancer prevention

Falk, M

Dissertation, Linköpings universitet, Institutionen för klinisk och experimentell medicin, Dermatologi och venerologi. Linköpings universitet, Hälsouniversitetet, 2007.

Vascular Occlusion in a Porcine Flap Model: Effects on Blood Cell Concentration and Oxygenation

Bergkvist M, Zötterman J, Henricson J, Iredahl F, Tesselaar E and Farnebo S.

Plast Reconstr Surg Glob Open. 2017 Nov; 5(11): e1531.

Assessment of microvascular and metabolic responses in the skin.

Iredahl F

Dissertation, Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten, 2016.

Changes in skin microcirculation during radiation therapy for breast cancer

Tesselaar, E, Flejmer AM, Farnebo S and Dasu A.

Acta Oncologica, Vol 56, Issue 8, 2017.

A cool response – the influence of ambient temperature on capillary refill time A cool response – the influence of ambient temperature on capillary refill time

John RT, Henricson J, Junker J, Jonson CO, Nilsson GE, Wilhelms D and Anderson CD.

J Biophotonics, Jan 31, 2018.

Assessing microcirculation dynamics during gait in the lower limbs by non-contact polarized spectroscopy

Florindo M,  Silva H, Rodrigues LM.

Biomed Biopharm Res, (15)2, p189-195, 2018

Exploring the perfusion modifications occuring with massage in the human lower limbs by non-contact polarized spectroscopy.

Rocha C, Macedo A, Nuno S, Silva H, Ferreira H, Rodrigues LM.

Biomed Biopharm Res, (15)2, p196-204 2018.

The tissue viability imaging system – Suitable method for discovering minimal skin changes in occupational screenings? Results of a cross-sectional field study.

Weistenhöfer W, Uler W, Bernet F, Drexler H.

Skin Research Technology, Feb 2019

Sensitivity to capsaicin in skin and airways in patients with symptoms elicited by odorous chemicals

Holst H,

Dissertation Danish Research Center for Chemical Sensitivities, Gentofte Hospital, University of Copenhagen.

Assessment of lower limb microvascular reactivity to dynamic posture changes by the Tissue Viability Imaging system – a preliminary approach

Silva H, Nuno S, Florindo M and Rodrigues LM.

Vascular Occlusion in a Porcine Flap Model: Effects on Blood Cell Concentration and Oxygenation.

Bergkvist M, ZöttermanJ, Henricson J, Iredahl F, Tesselaar E, Farnebo s.

Plastic Reconstr Surg Glob Open. 2017 Nov; 5(11): e1531


Abdlaty R, Fang Q

Tissue viability imaging of skin microcirculation following exposure to Cold Air (-110 C) and Cold Water (8 C).

Leahy M

Galway Univ, Ireland

Diffuse reflectance spectroscopy: getting the capillary refill test under one’s thumb.

Henricson J, John RT, Anderson CD and Wilhems DB.

J. Vis. Exp. (130), e56737, doi:10.3791/56737 (2017).

Assessment of oxygenation with polarized light spectroscopy enables new means for detecting vascular events in skin.

Bergkvist M, Henricson J, Bergstrand S, Strömberg T, Tesselaar E and Farnebo S.

Microvascular Research, Vol 30, July 2020.

short term sensory and cutaneous vascular responses to hand exercise.

Shaik SS, MacDermid JC, Birmingham T and Grewal R.

Clinical & Experimental Dermatology and Therapies (ISSN: 2575-8268).

Mast Cell Dependent Vascular Changes Associated with an Acute Response to Cold.

Meyer J, Gorbach AM, Liu WM, Medic N, and Young M.

2013 –

Novel interpenetrating polymer network provides significant and long-lasting improvements in hydration to the skin from different body areas. 

Falla T, Rodan K, Fields K, Bianchini R, Mahon C and Skoboviat C.

J of Cosmetic Dermatology, Volume19, Issue5, May 2020, Pages 1246-1253.

Hyaluronic acid accelerate re-epithelialization and alters protein expression in a human wound model.

Nyman E, Henricson J, Grafouri B, Anderson CD and Kratz G.

Plast Reconstr Surg Glob Open. 2019 May; 7(5): e2221.

Current-Induced Vasodilatation Specifically Detects, and Correlates With the Time Since, Last Aspirin Intake: An Interventional Study of 830 Patients.

Ramondou P, Hersant J, Fouquet O, Sempore WY, Abraham, P and Henni, S.

J of Cardiovascular Pharmacology and Therapeutics, 2020, November 7.

Microvascular effects of microneedle applications.

Hackethal J, Iredahl F, Henricson J, Anderson CD, Tesselaar E.

Skin Res Technol. 2020 Jul 14.

Innate local response and tissue recovery following application of high density microarray patches to human skin.

Muller DA, Henricson J, Baker SB, Togö T, Jayashi Flores CM, Lemaire PA, Forster A, Anderson CD.
Sci Rep. 2020 Oct 28:10(1). 18486. doc. 10.1038/S41598-020-75169-4.
Microvascular effects of microneedles with subsequent histamin application in the skin prick test.
Hackethal J.
Skin Res Technol. 2020 Oct 23. doi: 10.1111/srt.12969.
Man versus machine – comparison of naked-eye estimation and quantified capillary refill.
John RT, Henricson J, Anderson CD and Daniel Björk Wilhelms.
BMJ Journals, vol 36, Issue 8, 2019.
Studying the impact of different body positions, squatting, and unipodal flexion on perfusion in the lower limb: an exploatory study approach complemented with optical spectroscopy (TiVi).
Nuno S, Florindo M, Silva H and Rodriques, LM.
Biomed Biopharm Res. 2020;17(2):187-96.
To See or Not to See: A study on Capillary Refill.
Toll, R, Thesis, Linköping Unversity, 2021.
Micropuncture closure following high density microarray patch application in helthy subjects.
Henricson J, Muller DA, Baker SB, Iredahl F, Togö T and anderson CD.
Skin Res Tech, Volume28, Issue2, March 2022.
Local Response and Barrier Recovery in Elderly Skin Following the Application of High-Density Microarray Patches.
 Iredahl F, Muller DA, Togö T, Jonasson H, Baker B, Anderson CD and Henricson J.
Vaccines 2022, 10(4), 583;
In-Vivo Dose-Response Analysis to Acetylcholine-Pharmacodynamic Assessment by Polarized Reflectance Spectroscopy.
Henricson J, Sjöberg F, Iredahl T, Strömberg T and Wilhelms D.
Research Square, : February 2nd, 2022.

Book Chapters

Biophotonics methods in microcirculation imaging.

Leahy MJ, Enfield JG, Clancy NT, O´Doherty J, McNamara P and Nilsson GE,

Medical Laser Application, 22, 105-126, 2007.

Biophotonics Functional Imaging of Skin

Leahy MJ and Nilsson GE,

In Handbook of Photonics for Biomedical Science (Edited by V.V. Tuchin), CRC Press 2010, ISBN:978-1-4398-0629-6

Tissue Viability Imaging

O’Doherty J, Leahy MJ and Nilsson GE,

In Microcirculation Imaging (Editor: MJ Leahy), 165-195, 2012, Wiley-Blackwell.

Tissue Viability Imaging for Assessment of Skin Erythema and Blanching.

Nilsson GE,

In Non Invasive Diagnostic techniques in Clinical Dermatology (Eds: Berardesca, Maibach and Wilhelm), ISBN-978-3-642-32108-5, pp 187-199, 2014.

Tissue Viability Imaging

Nilsson GE,

In Biomedical Photonics Handbook (second edition) (Ed: Tuan Vo-Dinh). ISBN-9781439804445; CRC Press 2015.

Studies on Polarised Light Spectroscopy.

Bergkvist M.

Thesis, Linköping University, Sweden, 2019.